Sunday, 3 March 2013

US HIV baby 'cured' by early drug treatment


HIVThe human immunodeficiency virus (HIV) attacks the immune system
A baby girl in the US born with HIV appears to have been cured after very early treatment with standard drug therapy, researchers say.
The Mississippi child is now two-and-a-half years old and has been off medication for about a year with no signs of infection.
More testing needs to be done to see if the treatment would have the same effect on other children.
But the results could possibly lead to a cure for children with HIV.
If the girl stays healthy it would be only the world's second reported cure.
Dr Deborah Persaud, a virologist at Johns Hopkins University in Baltimore, presented the findings at the Conference on Retroviruses and Opportunistic Infections in Atlanta.
"This is a proof of concept that HIV can be potentially curable in infants," she said.

“Start Quote

Dr Hannah Gay
I just felt like this baby was at higher-than-normal risk and deserved our best shot”
Dr Hannah GayUniversity of Mississippi Medical Center
Cocktail of drugs
In 2007, Timothy Ray Brown became the first person in the world believed to have recovered from HIV.
His infection was eradicated through an elaborate treatment for leukaemia that involved the destruction of his immune system and a stem cell transplant from a donor with a rare genetic mutation that resists HIV infection.
In contrast, the case of the Mississippi baby involved a cocktail of widely available drugs already used to treat HIV infection in infants.
It suggests the treatment wiped out HIV before it could form hideouts in the body.
These so-called reservoirs of dormant cells usually rapidly re-infect anyone who stops medication, said Dr Persaud.
The baby was born in a rural hospital where the mother had only just tested positive for HIV infection.
Because the mother had not been given any prenatal HIV treatment, doctors knew the baby was at high risk of being infected.
Researchers said the baby was then transferred to the University of Mississippi Medical Center in Jackson.
Once there, paediatric HIV specialist Dr Hannah Gay put the infant on a cocktail of three standard HIV-fighting drugs at just 30 hours old, even before laboratory tests came back confirming the infection.
"I just felt like this baby was at higher-than-normal risk and deserved our best shot," Dr Gay said.

China parades foreign Mekong killers before execution



Convicted murderer Naw Kham is led from his cell in Yunnan, China (1 March 2013)

Naw Kham was shown on TV being led from his prison cell by police
Four foreign men have been executed in China for the murder of 13 Chinese fishermen on the Mekong river in 2011, after being paraded on state TV.
The men were put to death by lethal injection in Kunming, Yunnan province.
CCTV News broadcast live footage of the men being taken from their cells to the execution site, though it did not show the moment of death.
Many social media users in China have reacted angrily, condemning the broadcast as insensitive.
It is believed to be the first time in China's recent history that live footage of condemned criminals being taken to their execution has been broadcast.
Since CCTV is controlled by the Chinese authorities, there is no doubt that the green light was given by top government officials, the editor of BBC Chinese, Raymond Li, reports.
It seems that the Chinese government wants to send out a clear signal to the general public that they are taking very tough action against foreign criminals, he adds.
Some have applauded the move, but many Chinese internet users spoke out against the special programme, in what some are saying was a throw-back to the execution rallies of China's past.
Powerful warlord

Analysis

The case has attracted widespread public interest in China because of the brutality of the 2011 killings as well as the unusual circumstances in which China insisted on the right to conduct the trials of the non-Chinese nationals, despite neither the crime nor the arrests taking place on Chinese soil.
Now the decision to show live pictures on state TV of the four men being taken to the execution chamber has made it even more of an issue, pushing it onto the list of most-talked-about topics on Weibo, the Chinese version of Twitter .
Many posts applaud the tough justice. "The murdered Chinese crew can finally rest their souls," Hu Xijin, editor of China's Global Times newspaper writes. "It is necessary to pursue revenge and send a warning to those who kill Chinese people."
But others express unease about what they see as an unnecessary display of vengeance. "This shows the whole world that China still hasn't got rid of barbarianism yet," someone calling themselves You Niao says. "Does CCTV need to give everyone a blood bath?"
A prominent human rights lawyer, Liu Xiaoyuan writes; "Using two hours to broadcast live the process for these criminals facing the death penalty is a violation of the law."
Among the prisoners was Naw Kham, a Burmese man thought to have been one of the most powerful warlords in the Golden Triangle of Thailand, Laos and Burma.
China's state television channel CCTV aired an interview with Naw Kham on Thursday.
"I couldn't sleep properly over last two days. I miss my mother. It is really painful that I can't be with my children," Naw Kham told the channel.
"My mum didn't know when I was arrested, and I am worrying that she won't be able to take it when she finds out," he went on.
Announcing the execution on Twitter, state news agency Xinhua tweeted a photograph of Naw Kham with his hands clasped in front of his forehead. It is unclear when this picture was taken.
Xinhua has said the men had had their "legal rights fully respected" while on death row.
China's foreign ministry said the case highlighted its determination to tackle cross-border crime.
"I think an important message that this case sends is that it shows the determination of China and the governments of relevant countries to work hard together to combat cross-border crime," Hua Chunying spokesman for China's foreign ministry said.
Chinese television used to regularly broadcast the parading of condemned criminals in stadiums and through city streets on the way to executions, and although the practice largely stopped decades ago, exceptions remain, the BBC's John Sudworth in Shanghai says.
In 2008 a man who had murdered his mother was paraded in an open top truck on the way to his execution with a placard around his neck, detailing his crime. And a recent provincial TV show, in which death row prisoners were interviewed by a glamorous female presenter, attracted almost 40 million viewers.
River security
The 13 fishermen were found dead inside two Chinese cargo ships in October 2011 on the Thai side of the river.
State media said Naw Kham and his subordinates had collaborated with Thai soldiers in launching an attack on the ships, the Hua Ping and Yu Xing.
The other men were Hsang Kham from Thailand, Yi Lai, who is stateless, and Zha Xika from Laos, said the Xinhua news agency.
The group were arrested in Laos and brought to China in May last year, after Beijing said the attack had happened on board Chinese-flagged ships.
Beijing argued that the men should be extradited for trial - a move which some observers saw as an indication of the considerable political and economic clout China now exercises over its smaller neighbours, our correspondent reports.
In November, the men were found guilty of intentional homicide, drug trafficking, kidnapping and hijacking.
Two other members of the gang were also convicted - one received a death sentence with reprieve and the other eight years in prison.
Thailand launched an investigation into the allegations against nine of its soldiers in connection with the incident.
The attack came amid a wave of hijacking of vessels sailing on the Mekong which were blamed on gangs operating in the notorious drug-trafficking region.
China, Burma, Laos and Thailand launched joint security patrols on the Mekong in response.
Li Zhuqun, a senior international co-operation official at China's Ministry of Public Security said the gang had now been broken up, but that "efforts to ensure the safety of the Mekong River will continue".
"We will continue patrols and law enforcement co-operation with the other three countries to safeguard shipping on the river," he told China Daily.
Map of the Mekong River

Pakistan Karachi bomb blast kills dozens






At least 45 people have been killed by a bomb explosion in the Pakistani city of Karachi, police say.
The blast in the mainly Shia Muslim area of Abbas Town destroyed several buildings and set others on fire. Some reports spoke of a second explosion.
No group has yet said it planted the bomb, which went off near a mosque as worshippers left evening prayers.
Pakistan's Shia minority are the target of frequent sectarian attacks from Sunni militant groups.

Analysis

Shia Muslims make up about 20% of Pakistan's population of 180 million, and while sectarian violence targeting them is by no means a new phenomenon it is on the rise.
Human Rights Watch says that last year more than 400 Shias were killed in such attacks across the country.
Just in the first two months of this year, nearly 200 Shias - members of the Hazara community - have been killed in the south-western city of Quetta.
Karachi, where this latest anti-Shia bombing has taken place, is notorious for violence of various kinds.
But it is clear that the ability of the authorities to protect Shias is now being tested even more severely - and this as new elections are around the corner.
Political and religious leaders were quick to condemn the Karachi attack and promise help to the victims.
The explosion sent a huge column of smoke into the sky above Karachi and caused a power cut in part of the city.
Police are investigating whether it was a suicide attack.
Rescuers have been struggling to reach people trapped under the rubble.
Residents have been using car headlights to help the search for survivors, local media reports said.
Around 150 people were wounded by the explosion, officials said.
"I was watching television when I heard an explosion and my flat was badly shaken," Karachi resident Mariam Bibi told Reuters news agency.
"I saw people burning to death and crying with pain. I saw children lying in pools of their own blood and women running around shouting for their children and loved ones." she added.
Rescue work was delayed as some residents fired guns into the air in anger at the carnage, reports say.
Sectarian divide
Pakistan's main political and religious leaders rushed to condemn the attack - the latest to target the Shia minority.
Nearly 200 people were killed in two separate bombings targeting the Shia community in the south-western city of Quetta in January and February.
Some relatives of the victims there initially refused to bury their dead in protest at what they said was the failure of the authorities to protect their community from attack.
No group has yet admitted to carrying out the Karachi bombing, but correspondents say suspicion is likely to fall on Sunni militant groups.

Sunni and Shia Muslims

  • Muslims are split into two main branches, the Sunnis and Shias
  • The split originates in a dispute soon after the death of the Prophet Muhammad over who should lead the Muslim community
  • There are also differences in doctrine, ritual, law, theology and religious organisation
  • The great majority of Muslims are Sunnis
  • Pakistan - where Shias are a minority - has a history of sectarian bloodshed dating back to the 1980s
Groups such as Lashkar-e-Jhangvi regard Shia Muslims as heretics and have stepped up attacks in recent years.
They are thought to have set several training camps for militants and police seizures have shown they have access to large quantities of weapons and explosives, the BBC's M Ilyas Khan in Islamabad says.
Some activists called 2012 the worst year in living memory for attacks on Pakistan's Shia community.
But already this year bombings in the south-western of Quetta alone have killed nearly 200 people.
Last month Pakistan's Supreme Court called on the authorities to devise a strategy to protect Shia Muslims more effectively, given the increase in attacks.
Karachi - Pakistan's biggest city and commercial capital - has a long history of violence.
As well as a sectarian divide between Sunni and Shia, that city has also seen conflict between different ethnic communities - Pashtuns from north-west Pakistan, Mohajirs (immigrants from India following the Partition) and Sindhis.
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